1 Molecular Mechanisms for the Synchronized Transcription of the Three Complement C 1 q Subunit Genes in Dendritic Cells and Macrophages
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چکیده
Bachground: C1q is assembled in 1:1:1 ratio from three subunits demanding synchronized expression of three genes in a cluster – C1q deficiency causes lupus Results: A PU.1/IRF8-stimulated `core promoter’ appears to exist in this gene cluster Conclusion: A core promoter helps synchronize three C1q gene transcription Significance: This helps explain the highly conserved clustering of three C1q genes in all animal species including zebrafish
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تاریخ انتشار 2011